Notably, Tfh13 cells, a newly identified and functionally specialized Tfh cell subset, have been implicated as a key cell type regulating high-affinity and anaphylactic IgE responses in allergic diseases, including allergic asthma, due to the production of IL-13.24,31 Therefore, exploring whether Tfh cells, particularly the Tfh13 cells, mediate the relationships between SCFAs and allergic asthma would be of great significance for elucidating the underlying mechanism and developing new strategies for the prevention and treatment of allergic asthma. This evidence concerns the gene IGHE and allergic asthma.