TET2 and hepatocellular carcinoma: To validate the physiological roles of TET2 and YAP in HCC, we examined the sorafenib-resistant (RS) cells (Supplementary Fig. S1F) and found that the expression of YAP but not TET2 is substantially induced compared with wild-type cells (WT) (Supplementary Fig. S1F), which is consistent with previous findings [31].