TET2 and hepatocellular carcinoma: Given the functional role of YAP in HCC tumorigenesis and drug resistance, we further tried to uncover the regulation of YAP by TET2 and found that the phosphorylation level of YAP Ser127 (hereafter p-YAP) is significantly downregulated in sgTET2 HCC cells (Fig. 1E) and liver tissues of Tet2 knockout mice (Fig. 1F).