VEGFA and retinopathy of prematurity: However, zone 2 disease and stage 3 ROP were more prevalent in the LPC group than in the anti-VEGF group, with rates of 80.8% (181 patients) versus 61.2% (82 patients) for zone 2 and 91.9% (206 patients) versus 61.9% (83 patients) for stage 3 (p<0.001 for both).