To identify DUBs that are required to maintain KRAS protein abundance in cancer cells, we performed an siRNA screen in human colon cancer cell line HCT116 which carries a G13D mutation in KRAS. A commercial DUB siRNA library designed against 90 DUBs with each DUB targeted by 3 siRNAs (in most cases) was utilized. This evidence concerns the gene KRAS and malignant colon neoplasm.