Genome-wide association studies (GWAS) have associated SARM1 with amyotrophic lateral sclerosis (ALS) (Fogh et al., 2014; van Rheenen et al., 2016), and gain-of-function mutations in SARM1 are notably prevalent in individuals affected by ALS and other motor neurone disorders (Bloom et al., 2022; Gilley et al., 2021). This evidence concerns the gene SARM1 and motor neuron disorder.