Beyond its role in fibroblast activation, LCN2 regulates several oncogenic signaling pathways—including PI3K/AKT, STAT3, ERK/MAPK, NF-κB, and Wnt/β-catenin—that collectively promote tumor proliferation, immune evasion, and extracellular matrix remodeling [43,44]. The gene discussed is NFKB1; the disease is neoplasm.