Cis-MRBEE identified the basal ganglia, hippocampus, and oligodendrocytes as causal tissues and cell-type, with CR1 increasing the risk on AD and pTau while decreasing A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}$\beta $\end{document}42. This evidence concerns the gene CR1 and Alzheimer disease.