We conducted a cis-MVMR analysis at the CR1 locus, using tissue- and cell-type-specific expressions of the CR1 gene to: (1) evaluate the potential risk or protective role of CR1 in AD, A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}$\beta $\end{document}42 and pTau in CSF, and (2) identify the causal tissues involved. The gene discussed is CR1; the disease is Alzheimer disease.