Taken together with our previous publications using the same virus (strain, dose) and same animal models [4,10], this study suggests that while the PD-associated genes Lrrk2 and Snca contribute to host defense against reovirus T3D-induced encephalitis when acquired systemically, they do not influence disease outcomes (i.e., time-to-death and viral titres) when the virus is administered directly to the brain. This evidence concerns the gene LRRK2 and encephalitis.