Intriguingly, increased IFN-γ has been recently shown to play a beneficial role in inducing MGnD in AD mice.69 While some inflammatory processes were upregulated in microglia co-cultured with high-Aβ-secreting neurons, we also observed reduced protein levels of TREM2, APOE, SPP1, and GPNMB (Figures 7A–7G, S7A–S7C, and S7J–S7N), which were partially Aβ dependent (Figures 7J–7N and S7F–S7I). Here, GPNMB is linked to Alzheimer disease.