APOE and Alzheimer disease: Intriguingly, increased IFN-γ has been recently shown to play a beneficial role in inducing MGnD in AD mice.69 While some inflammatory processes were upregulated in microglia co-cultured with high-Aβ-secreting neurons, we also observed reduced protein levels of TREM2, APOE, SPP1, and GPNMB (Figures 7A–7G, S7A–S7C, and S7J–S7N), which were partially Aβ dependent (Figures 7J–7N and S7F–S7I).