Importantly, the NF-κB signaling pathway, TNF signaling pathway, rheumatoid arthritis, IL-17 signaling pathway, osteoclast differentiation, cytokine-cytokine receptor interaction, and chemokine signaling pathway were highly activated in periarticular CD14hi macrophages of Spry1-cKO mice (Figure 5E). Here, IL17A is linked to rheumatoid arthritis.