SPRY1 and psoriasis: The Gene Ontology pathway enrichment analysis of upregulated epidermal and dermal DEGs highlighted that the pathways involved in the development of psoriasis and PsA were activated in Spry1-cKO skin lesions, including keratinization, Th17 cell differentiation, leukocyte chemotaxis, cytokine production, cytokine-mediated signaling pathways, bone resorption, and osteoclast differentiation (Figure 2, E and F).