SPRY1 and ankylosing spondylitis: CXCL10 gene expression was found to be significantly upregulated in the epidermis/keratinocytes of Spry1-cKO mice as well as in the PsA lesional skin compared with psoriasis lesional skin and ankylosing spondylitis normal skin (GEO GSE186063), indicating a stronger correlation between CXCL10 upregulation and PsA.