To determine whether SPRY1 expression in the skin is more strongly correlated with PsA than with psoriasis, we analyzed SPRY1 gene expression using GSE205748 and GSE186063 in the NCBI’s Gene Expression Omnibus (GEO) in lesional and nonlesional skin from patients with psoriasis or PsA, as well as in normal skin from patients with ankylosing spondylitis (21, 22). This evidence concerns the gene SPRY1 and ankylosing spondylitis.