Among all differentially expressed genes (DEGs) in the epidermis and dermis (Spry1-cKO vs. control, adjusted P < 0.05 and |log2FC| > 0.5), we observed significant similarities in hallmark profiles of psoriasis-related gene expression patterns between skin lesions of Spry1-cKO mice and patients with psoriasis (Figure 2, B and C). This evidence concerns the gene SPRY1 and psoriasis.