We demonstrated that expression of the miRNA, miR-30a, in WAT positively correlates with insulin sensitivity in mice and people and that adenovirus (Adv) delivery of miR-30a into subcutaneous WAT (i.e., inguinal WAT [iWAT]) enhances insulin sensitivity in mice with diet-induced obesity (12, 15). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.