Given that miR-30a levels are high in WAT in physiologic conditions (C57BL/6 mice fed standard chow) and reduced with diet-induced obesity (12), we overexpressed miR-30a in WAT (miR-30afat) by crossing Adipoq-Cre mice with miR-30aL/L mice. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.