Among these 10 KO genes for phenylalanine, tyrosine, and tryptophan biosynthesis, TYRA2, AROK, AROC, AROD, AROA2, AROB, PHEA, PHEB, and K24018 were down-regulated, and TRPB was up-regulated in the gut microbiota of stroke patients with T2D (Figure 4D). Here, LNCAROD is linked to type 2 diabetes mellitus.