Four interactions including ST7L-ADSS2, FHIT-CHDH, LARP4B-LHPP, and RBFOX3-MPRIP were replicated in an independent set of 856 non-Caucasian participants who were associated with bladder cancer risk, where they developed an iPRS (Interaction-empowered polygenic risk score) that incorporates the interactions which showed a hazard ratio of 1.81 when comparing the highest tertile to the lowest tertile, and achieved an AUC of 0.91 which indicated an enhanced bladder cancer screening [41]. The gene discussed is MPRIP; the disease is urinary bladder cancer.