While Brundula et al. came to the conclusion that minocycline blocked the transmigration of leukocytesdue to markedly decreased MMP-2 and MMP-9 expression levels [3], Yang et al. assumed that minocycline inhibited the migration and invasion of colon cancer cells by directly binding the Src kinase Lyn [8]. The gene discussed is LYN; the disease is colonic neoplasm.