MAP2K7 and cardiac hypertrophy: MEK/ERK and P65, as essential regulators of MI, have been reported in a large number of studies; for example, the MEK/ERK pathways are activated during cardiac hypertrophy after myocardial infarction in rats and oxygen-glucose deprivation/reperfusion (OGD/R) -induced H9c2 cells [29, 30].