The GSE161151 database sample is an 8-week C57BL/6 mouse model of myocardial ischemia-reperfusion injury (45 min of ischemia and 24 h of reperfusion) found that the expression of PLAC8 in the myocardial infarction zone samples showed a significant downward trend. The gene discussed is PLAC8; the disease is myocardial infarction.