TMED3 and neoplasm: Although we elucidated the potential relationships among AKT, Sp-1, TMED3, and ZBTB7A in GBM metabolic regulation and tumor progression, further experimental validation is needed to determine whether TMED3 directly regulates ZBTB7A transcription by binding to its promoter region and whether this direct regulation is mediated in an AKT-dependent manner.