COL4A3 and chronic kidney disease: Mice fed an adenine-rich diet for several weeks and mice with global deletion of the collagen type IV alpha 3 chain (Col4a3−/−), which are both models of progressive CKD, develop lung inflammation and injury, with secretion of inflammatory cytokines by various cell types, including bronchial epithelial cells, and leukocyte infiltration in the alveolar and bronchial walls [148, 149].