Various strategies, including the use of small‐molecule inhibitors, such as YM155 and FL188 (Wang et al. 2011; Ling et al. 2012); antisense oligonucleotides, such as LY2181308 and SPC3042 (Martínez-García et al. 2019); and small interfering RNAs (siRNAs) (Liu et al. 2013; Khan et al. 2016; Zhang et al. 2017) have been employed to knock out BIRC5 in cancer cells. The gene discussed is BIRC5; the disease is cancer.