Bulk RNA sequencing of colon tissues from FLNAR and FLNAQ animals on day 10 of DSS-induced colitis (the peak of disease) confirmed that FLNAR mice had less inflammation as indicated by a reduced expression of inflammatory genes (Il1b, Cxcl3, Cxcl2, or Trem1) (Weber et al., 2014). Here, TREM1 is linked to colitis.