Further, the FLNA editing state influenced genes associated with proliferation, cancer, and stress response, with some being upregulated in FLNAR (e.g., Naca, Myof, Smoc2, and Hprt) (Gong et al., 2010; Dong et al., 2019; Su et al., 2016; Wang et al., 2021) and others being upregulated in FLNAQ ECs, like the AP-1 transcription factor complex (Atf3, Fos, and Jun) (Wu et al., 2021) (Fig. 1 D, Fig. S1, B–D, and Table S2). Here, JUN is linked to cancer.