A more recent cohort of 973 non‐Hispanic White youth with obesity (age range 3–17.9 years) showed that the development of prediabetes is negatively associated with MCRI measured by the ratio of the incremental areas under the curve (AUC) of C‐peptide to AUC of insulin during a 2‐h OGTT [31]. The gene discussed is INS; the disease is prediabetes syndrome.