Conversely, interfering with LOX‐induced collagen fiber crosslinking reduced the ECM content and tumor stiffness, leads to improved T‐cell migration and increased efficacy of anti‐PD‐1 blockade.[85] While measurements of tissue stiffness have been introduced as clinical indicators to detect tumors, nothing was previously known about the tensional state of individual ECM fibers in human tissues. The gene discussed is LOX; the disease is neoplasm.