GATA3 and ductal breast carcinoma in situ: In DCIS, the panCK signal is sparser than in invasive carcinomas, and the morphology usually resembles that of ducts with a neoplastic expansion of the epithelial compartment.[68] In invasive carcinomas, numerous GATA3+ & panCK+ cells are not organized in circular lobules or ducts, as observed in healthy and DCIS tissues (Figure 3A,B), but are rather organized in streaks with an haphazard and destructive growth (Figure 3C).