This is particularly true for Fibronectin, one of the most abundant proteins distributed ubiquitously in the ECM, that plays a crucial role in cell‐ECM interactions and as driver of tumor growth and metastasis.[3, 37, 38, 39] The affinity of many of its binding partners is regulated by Fibronectin's fiber tension, including the closed conformation of Tissue transglutaminase 2 (TG2),[35] as well as interleukin‐7 (IL‐7),[40] and integrin αVβ3 versus α5β1. This evidence concerns the gene FN1 and neoplasm.