Nevertheless, the relaxation of Fibronectin fibers correlates, and might even be a characteristic mechano‐chemical signature for cancer progression, as high‐grade invasive carcinomas, which are associated with increased tumor aggressiveness and invasiveness, are richer in untensed Fibronectin fibers than intermediate‐grade invasive carcinomas (Figure 5). The gene discussed is FN1; the disease is invasive carcinoma.