TP53 and neoplasm: Immunoprecipitation confirmed that p53 and Cyb5r3 interact on purified LDs from tumor cells (Figure 4C; Figure S4G, Supporting Information), and Cyb5r3 is a robust LD protein.[19] Knocking down Cyb5r3 significantly increased p53 protein levels (Figure 4D,E; Figure S4H–J, Supporting Information).