MDM2 and neoplasm: A key advancement of our study lies in resolving the paradox of cytoplasmic p53 accumulation correlating with poor prognosis in patients with PDAC.[42] Although earlier work interpreted cytoplasmic p53 as a dysfunctional pool,[26] imaging revealed that much cytoplasmic p53 colocalizes with LDs, where it undergoes MDM2‐mediated degradation rather than exerting tumor‐suppressive functions.