PKM and cancer: A reprogrammed energy metabolic pattern generates sufficient materials for macromolecular biosynthesis and induces a more acidic environment for cancer cells to meet the needs for rapid proliferation and an invasive phenotype of tumor cells.[47] Our data indicated that LINC01094 promoted glycolytic metabolism by regulating PKM2 and enhanced the aggressive growth and metastasis of BC cells markedly in vitro and in vivo.