HIF1A and breast cancer: Previous studies have reported that PKM2 promotes the transactivation of HIF‐1α‐targeted genes (including PKM2 itself), thereby forming a positive feedback loop that triggers a cascade reaction in aerobic glycolysis and cancer progression.[30] Consistently, increased expression of LINC01094 enhanced PKM2 levels in BC cells, while its deletion led to a significant reduction in PKM2 expression (Figure 5E,F).