m6A modifies RNA through a dynamic interaction between three homologous factors: “writers” (methyltransferases), “erasers” (demethylases), and “readers” (binding proteins).[22] Knockdown of the methyltransferases METTL3 or METTL14, rather than the demethylases FTO or ALKBH5, significantly reduced LINC01094 expression in BC cells (Figure 2D; Figure S2D,E, Supporting information). This evidence concerns the gene ALKBH5 and breast cancer.