Older age, coronary artery disease (CAD), peripheral arterial disease, nephropathy, retinopathy, a long duration of DM, obesity, hypertension, and elevated N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) are all factors that contribute to an increased risk of HF in individuals with diabetes [1–3]. The gene discussed is NPPB; the disease is diabetes mellitus.