Both cell types co‐expressed the integrin heterodimer ITGA6/ITGB4 (Figure 4a), which has been linked to tumor metastasis via Laminin‐332‐mediated activation of mTOR and MAPK signaling pathways (Figure S3e, Supporting Information).[32, 33] Notably, we found that LAMC2, encoding the γ2 chain of Laminin‐332, which is a ligand of the integrin heterodimer (ITGA6/ITGB4),[34] was exclusively expressed and spatially localized to Tum_1 cells, with notably high expression in the T3 stage sample HPCP5 (Figure 4b,c). Here, MTOR is linked to neoplasm.