The interaction of LAMC2 with ITGA6/ITGB4 activates downstream signaling pathways that enhance tumor invasiveness, a mechanism also observed in other malignancies such as pancreatic ductal adenocarcinoma, colorectal cancer, and lung adenocarcinoma.[42, 43, 44]LAMC2’s elevated expression in PSCC and its association with basal‐like, stemness‐enriched subpopulations underscore its potential as a therapeutic target. Here, ITGB4 is linked to neoplasm.