We also explored the interaction between stromal cells and tumor basal stem‐like cells and observed a strong communication probability between Laminin‐332 (via LAMC2) and ITGA6/ITGB4, both endogenously (between Tum_1 cells) and exogenously (from fibroblasts to Tum_1 cells), while FN1 signaling predominantly governed fibroblast interactions with other cell types, independent of integrin receptors (Figure 4i). The gene discussed is ITGA6; the disease is neoplasm.