HMGB1 and impulse control disorder: During ICD, dying cells express and release of DAMPs that act through a diversity of mechanisms to increase antigen cross‐presentation and provide an inflammatory context for generating antigen‐specific T‐cell responses.[50] We next investigated if RT‐mediated cell death was associated with several common and widely accepted biochemical hallmarks of ICD, including adenosine triphosphate (ATP) actively secreted, calreticulin (CRT) cell surface exposure and high mobility group protein B1 (HMGB1) passively released.