Therefore, the simultaneous blockade of TGF‐β and VEGF with Y332D can ameliorate these effects by reducing abnormal collagen accumulation and vascular barriers and can reverse tumor‐intrinsic and RT‐induced TGF‐β‐ and VEGF‐dependent ECM remodeling, EMT, neovascularization, radioresistance, and immunosuppression. This evidence concerns the gene VEGFA and neoplasm.