HK2 and esophageal squamous cell carcinoma: For example, LINC00520 promotes glycolysis in osteosarcoma by upregulating ENO1 protein expression via blocking FBXW7‐mediated ENO1 ubiquitination and proteasomal degradation.[40] In gastric cancer, the interaction between lncRNA CCAT1 and splicing factor PTBP1 inhibits its degradation via ubiquitination, facilitating the transition from PKM1 to PKM2, thereby enhancing glycolysis.[41] In the present study, PDIA3P1 promoted glycolysis in ESCC by upregulating the expression of GLUT1 and HK2.