SOX2 and esophageal squamous cell carcinoma: For instance, LncRNA CASC9 is overexpressed and exerts oncogenic effects by recruiting EZH2 and subsequently altering H3K27me3 levels to negatively regulate PDCD4 expression.[34] LINC00941 is upregulated in ESCC, exacerbating tumor progression by forming a positive feedback loop involving LINC00941‐ILF2/YBX1‐SOX2.[35] Similarly, our previous research identified that PDIA3P1 is overexpressed in ESCC and promotes tumor progression, but the underlying mechanisms remain unexplored.[10]