OTOF and sensorineural hearing loss disorder: Some SNHL is due to stereocilia or synaptic defects, although the hair cells themselves may remain functional.[153] Recently, gene therapy for otoferlin mutations is being tested in open‐label clinical trials, and early results illustrate the transformative potential of this approach.[25] However, otoferlin gene therapy requires patients to have this rare mutation as well as functional remaining hair cells, limiting its applicability to a small population.