Furthermore, we found 18 of C42B‐ABi specific SE driven genes are transcription factors and up‐regulated in C42B‐ABi cells (Figure 1D; Table S3, Supporting Information), which could be highly correlated with malignant progression of prostate cancer, such as ELF3, reported to orchestrate a positive feedback loop with ESE1 activates NF‐κB and drives prostate cancer progression.[30] We further note that the top‐ranked genes ATF3 and NR2F1 have been implicated in prostate cancer. Here, ATF3 is linked to Familial prostate cancer.