TNF and neoplasm: However, the function of plasmacytoid DCs remains controversial, with studies indicating their contribution to immunosuppression,[71, 72, 73] whereas the production of IFNα/β and TNFα indicates their antitumor potential.[74] Further validation through well‐designed trials and clinical studies is necessary to elucidate the function of plasmacytoid DCs in tumor carcinogenesis.