This study aims (1) to evaluate and compare serum vitamin C and pentraxin 3 (PTX3) levels before and after hemodialysis in patients with CKD and (2) to assess the correlation between serum vitamin C levels and pentraxin 3 levels in CKD patients undergoing hemodialysis and explore the influence of comorbid conditions such as diabetes mellitus and hypertension. The gene discussed is PTX3; the disease is chronic kidney disease.