CXCL12 and neoplasm: Furthermore, TDSFs induce stromal cells within the PMN to produce CXCL12, establishing a chemotactic gradient that recruits immunosuppressive leukocytes—including neutrophils, MDSCs, and macrophages—to create a pro‐TME characterized by immune tolerance and stromal remodeling [68]. Additionally, tumor‐derived CCL2 recruits MDSCs and CD4+ cells to premetastatic organs [28, 69].