SIRT1 and Sepsis: To determine whether 3,4‐cPP‐mediated SIRT1 expression in macrophages or endothelial cells is essential for its protective effect against sepsis, we created mice with endothelial cell‐specific Sirt1 conditional knockout (EC–Sirt1 cKO) and macrophage‐specific Sirt1 cKO (MФ–Sirt1 cKO), as previously described [31, 35].