Also, NRF2E79Q activating mutation may interact with other mutations such as CTNNB1 mutation in H358, and the PIK3CA mutation in H596 which could impact MYC and YAP1 signaling and thus impacts the trans-differentiation in NSCLC directly or indirectly [41, 42, 44–46]. Here, MYC is linked to non-small cell lung carcinoma.