FOXP3 and neoplasm: To gain transcriptome-wide insights into the Foxp3-dependent gene program within intratumoral Treg cells, we performed scRNA-seq profiling of tumor-infiltrating Treg cells isolated from Foxp3AIDR26WT and Foxp3AIDR26TIR1(F74G) mice following 15 days of continuous Foxp3 degradation.