FOXP3 and neoplasm: The observed high rate of division of tumoral Treg cells was associated with their selective loss of function upon Foxp3 degradation manifested in tumor regression and enhanced anti-tumor immune responses in the absence of major adverse effects including inflammatory disease and wasting typically associated with wholesale ablation of Treg cells in experimental models of cancer54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64.