FOXP3 and neoplasm: To characterize the heterogeneity of tumor Treg cells with and without Foxp3 degradation, we performed a coarse clustering analysis, identifying four clusters: (1) a Gata3hi, Th2-like cluster; (2) a Cxcr3hi cluster; (3) a Tbx21hi, Th1-like cluster; and (4) an Mki67hi, proliferating cluster (Figure 7l–m).