FOXP3 and autoimmune disease: Contrary to adult mice, Foxp3 degradation in neonates led to severe autoimmune disease featuring pronounced T cell activation (Figure 5h, Extended Data Figure 8c), myeloproliferation (Figure 5i, Extended Data Figure 8d), and tissue inflammation (Figure 5j–k, Extended Data Figure 8e) similar to those in Foxp3-deficient Foxp3GFPKO mice indicative of a loss of Treg function.