In this regard, hepatitis and liver damage, associated with a marked immune infiltration, elevated serum alanine aminotransferase (ALT) and diminished albumin in Treg-depleted Foxp3DTR mice, were undetectable in Foxp3AIDR26TIR1(F74G) mice after four weeks of continuous Foxp3 degradation (Figure 1i–k). The gene discussed is FOXP3; the disease is hepatitis A virus infection.