The 16p12.1 risk locus encompasses a 120-kb region spanning KDM8, NSMCE1, and IL4R that has been associated with asthma 31,32; the region contains eQTLs for both NSMCE1 (expressed in esophageal mucosa, monocytes, CD4 + T cells) and IL4R (expressed in esophageal mucosa, monocytes), and associated variants also interact with IL4R via chromatin looping. Here, IL4R is linked to asthma.