C-MYB promotes the proliferation and differentiation of hematopoietic stem cells and may directly impact CD8 + T cell differentiation and survival 64, whereas STAT5 has well-known roles in inflammatory signaling, especially TSLP-induced Th2 signaling in EoE, mast cell activation in atopic dermatitis, IL-5 signal transduction in eosinophils, and activation of innate lymphoid cells (ILC2) 42,65–67. Here, STAT5A is linked to eosinophilic esophagitis.