The risk locus at 11q13.5 is located between EMSY (also known as C11orf30) and LRRC32; functional studies suggest a role for both genes in EoE 24,43, and the locus is also associated with eosinophil counts 28,44, asthma 45, atopic dermatitis 46, allergic rhinitis 27, serum IgE levels 47, and Crohn disease 48. The gene discussed is IGHE; the disease is eosinophilic esophagitis.