Loss- or gain-of-function mutations in the CACNA1A gene, encoding the α1A (Cav2.1) P/Q-type Ca2+ channel subunit, may lead to ataxia, hemiplegic migraine, epilepsy, or cognitive disability (Indelicato et al., 2018). This evidence concerns the gene SERPINA1 and familial or sporadic hemiplegic migraine.