While further studies are required to establish a role for Wnt/β-catenin signaling in regulating intrinsic DCIS cell invasion, SEMA7A-mediated β-catenin signaling in macrophages could be regulating migration through increased cytoskeletal dynamics, as well as matrix remodeling and cell invasion through EMT activation. The gene discussed is SEMA7A; the disease is ductal breast carcinoma in situ.