Phosphorylation of SR proteins impact their subcellular localization, association with the spliceosome complex, and splicing activity[49].SRSF5 and SRSF3 were reported to be overexpressed in oral squamous cell carcinoma (OSCC), and necessary for OSCC cell proliferation, cell cycle progression, and in vivo tumor formation. This evidence concerns the gene RNPS1 and oral cavity squamous cell carcinoma.