ERBB2 and breast cancer: According to the LASSO regression in clinical B-mode with CEUS and TIC of CEUS characteristic groups, seven features related to HER-2 positive breast cancer, including tumor size (cm), echotexture, strip-shaped echoic, macrocalcifications, microcalcifications, perfusion defects, and fall time (FT) of TIC, were selected (Figure 3).