The main keywords were "primary sclerosing cholangitis," "bile acids," "ursodeoxycholic acid," "cirrhosis," "farnesoid X receptor," "inflammatory bowel disease," "risk factors," and "liver disease."<h4>Conclusion</h4>There is a correlation between gut microbiota and PBC, and the role of gut microbiota in the pathogenesis and treatment of PBC will continue to be a future research direction. Here, NR1H4 is linked to Cirrhosis.