CRP and arthritic joint disease: Comparing the middle inception cohort to the latest cohort revealed several changes specific to women: mean CRP levels decreased significantly (mean difference 16, 95% CI 9.81–22.15, p < 0.001); the prevalence of radiographic arthritis decreased from 49.4% in the middle cohort to 31.5% in the latest cohort (p < 0.001); angina at baseline decreased from 6.1% in the middle cohort to 1.9% in the latest (p = 0.018).