Direct mechanisms include activation of the coagulation cascade by the tissue factor expressed by cancer cells, promotion of coagulation complex formation by microparticles carrying TF and phosphatidylserine released by cancer cells, and direct platelet activation by podoplanin (PDPN) via the C-type lectin-like receptor 2 (CLEC-2) receptor. The gene discussed is CLEC1B; the disease is cancer.