CUR can also alleviate mitochondrial damage in skeletal muscle cells of COPD rats by activating PGC-1α/SIRT3 signaling (Zhang et al., 2017) and attenuate airway inflammation and airway remodeling in a COPD mouse model, which was closely related to inhibiting BEAS-2B cell proliferation and inhibiting the activation of NF-κB and cyclooxygenase-2 (COX-2) expression (Yuan et al., 2018). Here, PPARGC1A is linked to chronic obstructive pulmonary disease.