SOD2 and chronic obstructive pulmonary disease: In addition, high-level SIRT3 can prevent SOD2 from decreasing and can also improve the mitochondrial oxidative stress of cigarette smoke extract (CSE)-treated airway epithelia, which suggests that SIRT3 might contribute to the suppression of COPD pathogenesis by inhibiting mitochondrial oxidative stress via the modification of SOD2 (Zhang et al., 2020).