SAA (20 and 40 μM) reduces AS by preventing inflammation via insulin-inducible gene (Insig)1, renal cancer chromosome 8 (Trc8), and Insig2-mediated ubiquitylation and recombinant 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) degradation in a dose-dependent manner (Xie et al., 2023). The gene discussed is HMGCR; the disease is renal carcinoma.