Body weight↓, fasting blood glucose levels↓, serum lipid↓,visceral fat weights↓, adipocyte size↓, lipid droplets in hepatocytes (hepatic steatosis), uterus weight↑, expression of ER-α/ER-β in the uterine↑, PPARγ↓, GLUT4↑, plin↓, ER-α↑, ER-β↑. The gene discussed is ESR2; the disease is fatty liver disease.