In addition, SNS reversed the reduced expression of PSD95, SYN, neuroligin-1 and GAP43 proteins in the DRN brain region MS co-CUMS model, in line with previous depression models (McEwen et al., 2012; Liu and Aghajanian, 2008) and some antidepressant research (Li et al., 2010; Voleti et al., 2013). The gene discussed is DLG4; the disease is major depressive disorder.