Moreover, MS-CUMS decreased CaSR activity in the DRN, and increased CaSR expression in DRN was found to reverse depression-related behaviours and lead to synaptic structural resonance and increased expression of synapse-associated proteins, suggesting that CaSR is a crucial mediator of MS-CUMS-induced behaviours and synaptic abnormalities. The gene discussed is CASR; the disease is depressive disorder.