At differentiation stage of brain development, EZH2 is required for switching Intermediate Progenitors cells fate from neurogenic to astrogenic by H3K27 trimethylation of Neurog1 promoter (Hirabayashi et al., 2009) (Figure 2).One of the well-known pieces of evidence showcasing the role of PRC2 complex in neurodevelopment comes from Weaver syndrome (WVS) studies. Here, EZH2 is linked to Weaver syndrome.