Interestingly, mutations in genes encoding for the factors that write or read H3K36 methylation, such as NSD1, ASH1L, SETD2, and NSD2, have been linked to NDD with autistic features or cognitive deficits, further stressing the importance of H3K36 metabolism in neurodevelopment (Wilson et al., 2022). This evidence concerns the gene SETD2 and Neurodevelopmental delay.