DNMT3A and overgrowth syndrome: Besides, specific heterozygous mutations of DNMT3A has been linked to DNMT3A overgrowth syndrome or Tatton-Brown Rahman syndrome (TBRS; OMIM 615879), an NDD characterized by IDD, overgrowth, craniofacial abnormalities, anxiety, and ASD (Tatton-Brown et al., 2014).