For example, mutations in the SETD2 gene, which encodes a methyltransferase responsible for H3K36me3, have been associated with ASD (case report) and neurodevelopmental disorders with or without macrocephaly overgrowth, highlighting the importance of this modification in brain development (Chen et al., 2021; Pappas and Rabin, 1993). This evidence concerns the gene SETD2 and neurodevelopmental disorder.