Additionally, emerging evidence links specific ERBB4 variants to the ALS-FTD continuum, demonstrating that the c.2136 T > G (p.I712M) mutation can reduce autophosphorylation of the ERBB4 protein following NRG1 stimulation in vitro (Sun et al., 2020). Here, NRG1 is linked to amyotrophic lateral sclerosis.