ERBB4 and amyotrophic lateral sclerosis: NRG1-III exhibits significant benefits in ALS by preserving motor neuron function and survival, particularly by maintaining neuromuscular junctions and reducing neuroinflammation in SOD1G93A mice (Lasiene et al., 2016; Modol-Caballero et al., 2020), highlighting the therapeutic potential of targeting the NRG1-ERBB4 axis in ALS.