While patients carrying ERBB4 variants rarely exhibit cognitive dysfunction, these variants have been identified in individuals with FTD and ALS-FTD (Dols-Icardo et al., 2018; Gromicho et al., 2020; Sun et al., 2020; Tábuas-Pereira et al., 2022; Cai et al., 2024), suggesting that the role of ERBB4 in cognitive impairment and neurodegenerative diseases warrants further investigation. This evidence concerns the gene ERBB4 and amyotrophic lateral sclerosis.