Among 23 ALS patients with rare ERBB4 variants, the average onset age was 46.9 ± 10.3 years, significantly lower than that of the overall ALS cohort (Shen et al., 2024) (52.6 ± 11.2; T = 2.6, p = 0.015). Here, ERBB4 is linked to amyotrophic lateral sclerosis.