MAPK8 and Alzheimer disease: In vivo experiments have also found that the abnormal aggregation of Aβ can cause chronic endoplasmic reticulum stress, consequently causing dysregulation of the unfolded protein response (UPR) signaling pathway and cellular stress response, further activating MAPK kinases such as JNK and p38 and promoting AD-mediated neuronal apoptosis and neuroinflammation.