Studies have further shown that the downstream target of AMPK, the SIRT1-FOXO1/3 axis, plays a vital role in exercise-enhanced PINK1/PARKIN pathway-mediated mitophagy in AD mice (Zhao et al., 2023), and the crosstalk between the PINK1/PARKIN pathway and other pathways needs to be further studied. The gene discussed is PRKN; the disease is Alzheimer disease.