Exercise training regulates multiple signaling pathways related to AD pathophysiology, including the PI3K/Akt, Wnt/β-catenin, AMPK-related, MAPK, NF-κB, PINK1-PARKIN, JAK/STAT, and TREM2 signaling pathways (Figure 1). The gene discussed is NFKB1; the disease is Alzheimer disease.