Among these processes, the AdipoR1/ phospholipase C (PLC)/ protein phosphatase 2A (PP2A) signaling pathway may play an important role in exercise training, promoting TFEB nuclear translocation and enhancing the autophagy-lysosomal path in the brain cells of AD mice (Jian et al., 2022). The gene discussed is ADIPOR1; the disease is Alzheimer disease.